SYNDECAN-1 AND RISK FACTORS ASSOCIATED WITH ITS CONCENTRATION IN ACUTE MYELOID LEUKEMIA PATIENTS

Abstract

The study included determining the syndicane-1 concentration in acute myeloid leukemia patients and comparing it with healthy cases, and studying the effects of some risk factors on its concentration in both patients and control group, complete blood count (CBC) including white blood cells, hemoglobin, platelets and blast in bone marrow has been determined, as well as, the concentration of urea, creatinine, the activity of lactic dehydrogenase, systolic and diastolic blood pressure and body temperature. The results showed a significant increase in the concentration of syndicane-1 in patients compared to healthy people, and its concentration increases significantly with age, smoking, body mass index (BMI), blood type (A), duration of disease, chemotherapy, diabetes menopause in women, WBC count, platelet count, hemoglobin and blast% in BM. Our results showed a significant increase in the concentration of creatinine, urea, lactate dehydrogenase activity, and body temperature (Tm) in patients compared to the control. The Pearson correlation coefficient (r) showed a positive correlation between syndicane-1 concentration and creatinine, urea, Tm, and LDH. We concluded that syndicane-1 concentration can be a strong biomarker for the diagnosis of acute myeloid leukemia and endothelial glycocalyx damage.